Response to Zhao and Huang’s Commentary Letter, “Conversion of Human Cardiac Progenitor Cells using Reprogramming Factors into Heterogeneous Cardiac Pacemaker-like Cells”, regarding our Manuscript: "Conversion of Human Cardiac Progenitor Cells into Cardiac Pacemaker-like Cells"
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چکیده
منابع مشابه
brief azacytidine step allows the conversion of suspension human fibroblasts into neural progenitor-like cells
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Cardiac stem cells (CSCs) can differentiate into cardiac muscle‑like cells; however, it remains unknown whether CSCs may possess the ability to differentiate into pacemaker cells. The aim of the present study was to determine whether angiotensin II (Ang II) could promote the specialization of CSCs into pacemaker‑like cells. Mouse CSCs were treated with Ang II from day 3-5, after cell sorting. T...
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Background & Aims: Myocardial infarction is a leading cause of human mortality in industrialized and developing societies. Limited restorative ability of of cardiomyocytes after ischemic changes can causes extensive damage lead to prominent chronic heart failure. At present, the application of certain drugs is touted as one of the main available approaches to inhibit the spread of the lesion an...
متن کاملCardiac Progenitor Cells
In the last few years we have witnessed one of most extraordinary revolutions in cardiovascular medicine, namely, an explosion of basic and clinical studies that support the notion that the diseased heart can be repaired by administration of stem cells, resulting in formation of functional new myocytes and vessels. Although the mechanism by which cell therapy improves cardiac function and anato...
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Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Abstract Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2020
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2020.03.010